Animal study compares modified Gengnianchun formula and androgens for improved ovarian function in stress-induced models, suggesting herbal options may be superior.
Chronic stress-induced hypercortisolism causes diminished ovarian reserve (DOR), contributing to infertility and miscarriage. Androgen supplementation is an emerging therapeutic approach for DOR. The traditional Chinese herbal decoction modified Gengnianchun formula (MGNC) has shown clinical efficacy in treating DOR. This study aimed to compare the effectiveness of MGNC with that of androgens in a stress-induced DOR mouse model.
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Gao et al. (2026) studied this question.
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