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March 19, 2026Food & Function2 citations

Ligilactobacillus salivarius Li01 enhances gut microbiota-derived indole-3-propionic acid to alleviate 5-fluorouracil-induced diarrhea in mice

PYPengyu YinBQBo QiuLXLvwan Xu

Key Points

  • The research aims to investigate how Li01 affects gut microbiota and its role in alleviating diarrhea caused by chemotherapy.
  • Administered Li01 to mice receiving 5-fluorouracil (5-FU).
  • Evaluated inflammation, oxidative damage, and intestinal barrier integrity.
  • Measured levels of gut microbiota-derived indole-3-propionic acid (IPA).
  • Assessed PXR activation related to IPA levels.
  • Li01 significantly reduced inflammation and oxidative damage in 5-FU-treated mice.
  • Restoration of the intestinal barrier was observed.
  • Elevated levels of gut microbiota-derived IPA were confirmed.
  • PXR activation was linked to the effects of Li01.

Abstract

Li01 administration alleviated 5-FU-induced diarrhea by mitigating inflammation and oxidative damage, and restoring intestinal barrier. Li01 exerted its benefits by elevating the level of gut microbiota-derived IPA, which activated the PXR.

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Cite This Study

Yin et al. (2026) studied this question.

synapsesocial.com/papers/69bb9321496e729e62981155https://doi.org/10.1039/d6fo00050a
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