Network pharmacology and bioinformatics analysis of the multi-target immune-inflammatory mechanisms of Shengma Gegen decoction in chronic urticaria

Miao Hu; Yirong Ma; Jiaming Li; Jinhong Wu

doi:10.5414/cp204855

March 17, 2026International Journal of Clinical Pharmacology and Therapeutics

Network pharmacology and bioinformatics analysis of the multi-target immune-inflammatory mechanisms of Shengma Gegen decoction in chronic urticaria

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Key Points

The aim is to explore how Shengma Gegen decoction can improve chronic urticaria by targeting various inflammatory mechanisms.
Utilized network pharmacology to identify key targets and pathways influenced by Shengma Gegen decoction.
Conducted bioinformatics analysis to evaluate the relationship between selected core targets and inflammatory pathways.
Analyzed the roles of specific targets such as MMP9, IL6, AKT1, IL1B, and TNF in modulating immune responses.
Shengma Gegen decoction upregulates anti-inflammatory pathways while downregulating pro-inflammatory pathways.
Key targets such as TNF and IL-17 play significant roles in managing chronic urticaria symptoms.
The findings support further experimental studies on the modernization of traditional formulations.

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Implication

Network pharmacology analyzes immune-inflammatory mechanisms in chronic urticaria, suggesting potential treatments.

Abstract

SMGG may ameliorate CU by coordinately regulating inflammatory pathways (AGE-RAGE, TNF, IL-17) and immune balance via core targets (MMP9, IL6, AKT1, IL1B, TNF). The study offers a mechanistic basis and target/pathway prioritization to guide future experimental work and the modernization of traditional formulations.

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Hu et al. (2026) studied this question.

synapsesocial.com/papers/69bb9321496e729e62981163 https://doi.org/10.5414/cp204855

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Network pharmacology and bioinformatics analysis of the multi-target immune-inflammatory mechanisms of Shengma Gegen decoction in chronic urticaria

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Network pharmacology and bioinformatics analysis of the multi-target immune-inflammatory mechanisms of Shengma Gegen decoction in chronic urticaria

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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