An AI Approach to Differentiating Lung Squamous Cell Carcinoma From Metastases of Other Origins

Key Points

• To evaluate the effectiveness of an AI-assisted approach in accurately diagnosing lung squamous cell carcinoma versus metastatic cancers.
• Conducted a cross-sectional analysis of lung SCC cases.
• Applied an AI-assisted diagnostic tool to identify misdiagnoses.
• Utilized orthogonal evidence to support diagnosis changes.
• A significant number of patients were initially misdiagnosed with other cancer types.
• AI intervention led to accurate differentiations in diagnosis.
• Changes in diagnosis may enhance prognostication and therapy selection for clinicians.