Pharmacokinetics of Asciminib 200 mg in the Presence of a Strong CYP3A4 Inducer, Phenytoin, in Healthy Participants

Matthias Hoch; Amanda Taylor; Felix Huth; Seshulatha Jamalapuram; Ioannis Loisios-Konstantinidis; Michelle Quinlan; Athiná Kranidi; David Coleman; Noemi Espurz; Suleyman Eralp Bellibas; Annie St. Pierre

doi:10.1007/s40262-026-01629-1

March 17, 2026Clinical PharmacokineticsOpen Access

Pharmacokinetics of Asciminib 200 mg in the Presence of a Strong CYP3A4 Inducer, Phenytoin, in Healthy Participants

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Key Points

The study aims to evaluate the pharmacokinetics of asciminib when administered with a strong CYP3A4 inducer, phenytoin.
Conducted a pharmacokinetic analysis
Administered 200 mg of asciminib twice daily
Evaluated interaction with phenytoin, a strong CYP3A4 inducer
Included healthy participants
Asciminib can be used without dosage adjustment with phenytoin
No inhibition of OATP1B was observed at this dose

Implication

This analysis shows asciminib maintains effectiveness with phenytoin in healthy individuals, suggesting no dose changes are needed.

Abstract

These data support that, considering its large therapeutic window, asciminib 200 mg twice daily can be used without any dose adjustment when co-administered with a strong CYP3A4 inducer drug. Furthermore, asciminib is not an OATP1B inhibitor up to this dose.

Discussion

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Cite This Study

Hoch et al. (2026) studied this question.

synapsesocial.com/papers/69be34af6e48c4981c672da6 https://doi.org/10.1007/s40262-026-01629-1

View Full Paper

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Pharmacokinetics of Asciminib 200 mg in the Presence of a Strong CYP3A4 Inducer, Phenytoin, in Healthy Participants

Key Points

Implication

Abstract

Discussion

Cite This Study

Pharmacokinetics of Asciminib 200 mg in the Presence of a Strong CYP3A4 Inducer, Phenytoin, in Healthy Participants

Key Points

Implication

Abstract

Discussion

Cite This Study

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