Chiral Borophosphate-Catalyzed Kinetic Resolution of Diaryl Tertiary Alcohols through Dehydration

Optically active diaryl tertiary alcohols are key moieties in natural products and pharmaceuticals, making efficient asymmetric synthesis highly desirable. Catalytic kinetic resolution is a practical strategy for accessing such chiral compounds, yet dehydration-based kinetic resolution methods remain scarce. Herein, we report a metal-free, dehydration-driven kinetic resolution of diaryl tertiary alcohols catalyzed by chiral borophosphates. A range of optically active diaryl tertiary alcohols was afforded in 29–60% yield and 51–98% ee with selectivity factors of 3.7–36.3.