ATP2C2–PLA2R1 axis underlies lipid metabolism modulation and invasion in papillary thyroid carcinoma mediated by a VGIC signature

Linlin Sun; Zhenxuan Sun; Wei Gao; Yinan Cao

doi:10.1007/s12672-026-04861-0

March 17, 2026Discover OncologyOpen Access

ATP2C2–PLA2R1 axis underlies lipid metabolism modulation and invasion in papillary thyroid carcinoma mediated by a VGIC signature

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Key Points

The research aims to investigate how the ATP2C2-PLA2R1 axis influences lipid metabolism and invasion in papillary thyroid carcinoma (PTC).
Analysis of VGIC gene signatures in PTC
Investigation of the ATP2C2 role in tumor metabolic changes
Assessment of tumor progression after VGIC targeting
Identified VGIC signatures as prognostic biomarkers for PTC
Targeting ATP2C2 reshaped the tumor's metabolic environment
Inhibition of PTC progression was observed with ATP2C2 modulation

Implication

Demonstrates that targeting VGICs improves prognosis in papillary thyroid carcinoma, suggesting new treatment possibilities.

Abstract

Specific VGIC gene signatures provide powerful prognostic biomarkers in PTC. Beyond improving prognosis, targeting these VGICs-especially ATP2C2-offers a novel approach to reshape the tumor metabolic microenvironment and inhibit PTC progression.

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Cite This Study

Sun et al. (2026) studied this question.

synapsesocial.com/papers/69be34d16e48c4981c672f70 https://doi.org/10.1007/s12672-026-04861-0

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ATP2C2–PLA2R1 axis underlies lipid metabolism modulation and invasion in papillary thyroid carcinoma mediated by a VGIC signature

Key Points

Implication

Abstract

Discussion

Cite This Study

ATP2C2–PLA2R1 axis underlies lipid metabolism modulation and invasion in papillary thyroid carcinoma mediated by a VGIC signature

Key Points

Implication

Abstract

Discussion

Cite This Study

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