Preoperative ctDNA Predicts Upstaging and Recurrence in High-Risk Non-Muscle Invasive Bladder Cancer Undergoing Radical Cystectomy | Synapse
March 21, 2026
Preoperative ctDNA Predicts Upstaging and Recurrence in High-Risk Non-Muscle Invasive Bladder Cancer Undergoing Radical Cystectomy
Key Points
To examine the relationship between detectable ctDNA and disease outcomes in high-risk non-muscle invasive bladder cancer prior to radical cystectomy.
Analyzed ctDNA status in patients with high-risk NMIBC prior to surgery.
Monitored recurrence-free survival (RFS) and rates of pathological upstaging after surgery.
Assessed associations with lymph node metastasis.
Detectable ctDNA is linked to lower RFS rates.
Patients with detectable ctDNA showed higher rates of pathological upstaging.
Increased likelihood of locally advanced disease with lymph node metastasis was observed.
Abstract
Detectable ctDNA status for high-risk NMIBC pre-RC was associated with worse RFS, increased risk of pathological upstaging, and locally advanced disease with lymph node metastasis.