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March 17, 2026PLoS ONEOpen Access

Correction: Blockade of mTOR ameliorates IgA nephropathy by correcting CD89 and CD71 dysfunctions in humanized mice

Alexandra Cambier Jennifer Da Silva Julie Bex Fanny Canesi Lison Lachize Neanne Aurélie Sannier Hélène Mathieu Erwan Boedec Amandine Badie Renato C. Monteiro

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Key Points

To investigate the effects of mTOR blockade on IgA nephropathy and associated immune dysfunctions in a humanized mouse model.
Utilized a humanized mouse model to study IgA nephropathy.
Applied mTOR blockade as an intervention.
Assessed dysfunction of CD89 and CD71 as biomarkers.
mTOR blockade led to corrected dysfunctions in CD89 and CD71.
Improvements in symptoms of IgA nephropathy were observed.
Overall enhancement in immune response metrics was noted.

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Implication

Correction notes improvement in IgA nephropathy through mTOR blockade in humanized mice, indicating potential therapeutic approaches.

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Cite This Study

Cambier et al. (2026) studied this question.

synapsesocial.com/papers/69be34f26e48c4981c6731ce https://doi.org/10.1371/journal.pone.0345118

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