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March 21, 2026ESMO Open0 citationsOpen Access

Molecular immune signature identifies microglia and NK cell infiltration as a favorable prognostic marker in adult-type high-grade glioma

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MPM. PatanèFondazione IRCCS Istituto Neurologico Carlo BestaLAL. AbballeBambino Gesù Children's HospitalSPS. Patrizi

Key Points

  • The aim is to identify immune signatures linked to favorable outcomes in high-grade gliomas.
  • Analyzed immune components in high-grade glioma samples.
  • Integrated data from innate and adaptive immune cell populations.
  • Evaluated correlations between immune infiltration and patient outcomes.
  • Identified specific infiltration of microglia and NK cells in long-term survivors.
  • Demonstrated a beneficial immune microenvironment associated with better prognosis.
  • Proposed the immune signature as a predictor for immunomodulatory treatment effectiveness.

Abstract

These integrated findings underscore the beneficial immune microenvironment in LTS HGG driven by specific innate and adaptive immune components. This immune signature may serve as a prognostic indicator and guide immunomodulatory therapeutic strategies for gliomas.

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Cite This Study

Patanè et al. (2026) studied this question.

synapsesocial.com/papers/69be35166e48c4981c673276https://doi.org/10.1016/j.esmoop.2026.106902
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