Key result
SAVR plus prolonged antifungal therapy successfully clears complicated Candida parapsilosis endocarditis.
Why the study?
Fungal infective endocarditis is rare and highly morbid, with Candida parapsilosis being an uncommon cause of native valve endocarditis increasingly linked to healthcare exposure.
Case Report (n=1)
This case highlights that early combined surgical intervention and targeted antifungal therapy can successfully treat high-risk healthcare-associated Candida parapsilosis native valve endocarditis complicated by massive arterial embolization.
May support combined surgery and antifungals in select Candida endocarditis; leaves open need for prospective validation before practice change.
Fungal infective endocarditis is a rare but highly morbid condition commonly caused by Candida species. Candida parapsilosis is an uncommon cause of native valve endocarditis and is increasingly associated with healthcare exposure. We report a 50-year-old woman with persistent Candida parapsilosis candidemia complicated by large native aortic valve vegetations and acute limb ischemia from arterial embolization, requiring surgical valve replacement and prolonged antifungal therapy.
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Potts et al. (2026) conducted a case report in Candida parapsilosis native aortic valve endocarditis (n=1). Surgical aortic valve replacement and antifungal therapy was evaluated on Clearance of candidemia and clinical stabilization. Surgical aortic valve replacement and prolonged antifungal therapy successfully cleared candidemia and achieved clinical stabilization in a patient with complicated Candida parapsilosis endocarditis.
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