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March 17, 2026International Dental JournalOpen Access

Chemokine-Like Receptor 1 Knockdown Suppresses Oral Squamous Cell Carcinoma Progression by Reducing Oxidative Phosphorylation

Yanzhu Lin Luodan Zhao Ying Huang Yuee Chen Quan Wan Zhiyuan Lu Xiangsong Zhang

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Key Points

The aim is to investigate the role of CMKLR1 in promoting oxidative phosphorylation and its impact on oral squamous cell carcinoma (OSCC).
Planned a knockdown experiment for CMKLR1 in OSCC cell lines.
Assessed changes in oxidative phosphorylation (OXPHOS) levels.
Evaluated the activation of the PI3K/AKT/PGC-1α pathway.
Knockdown of CMKLR1 significantly suppressed OXPHOS activity.
Targeting mitochondrial metabolism showed promise as a therapeutic approach.
Alterations in the PI3K/AKT/PGC-1α pathway were observed post-knockdown.

Implication

Knockdown of CMKLR1 reduces oxidative phosphorylation in oral squamous cell carcinoma, suggesting a potential therapeutic strategy.

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Cite This Study

Lin et al. (2026) studied this question.

synapsesocial.com/papers/69be35386e48c4981c673469 https://doi.org/10.1016/j.identj.2026.109479

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1CONSORT article: Single-cell sequencing analysis revealed CMKLR1+ macrophage as a subpopulation of macrophage with tumor-suppressive characteristics in oral squamous cell carcinoma2024 · 6 citations
2MicroRNA mediated signaling and metabolic reprogramming in oral squamous cell carcinomaReview · 2026
3DRP1-mediated mitophagy facilitates oral squamous cell carcinoma tumor cell survival under glucose restrictionOriginal Research · 2026 · 1 citations
4Integrative analysis identifies ALDOA and PGK1 as prognostic biomarkers and therapeutic targets in oral squamous cell carcinomaOriginal Research · 2026
5Targeting Oral Squamous Cell Carcinoma with Combined Polo-Like-Kinase-1 Inhibitors and γ-Radiation Therapy2024 · 4 citations

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