Inhibition of N‐Terminal Acetyltransferase C Mitigates Endoplasmic Reticulum Stress–Mediated Muscle Atrophy in Cancer Cachexia

Key Points

• This research investigates the role of N-terminal acetyltransferase C in muscle wasting linked to cancer cachexia.
• Used pharmacological inhibition of N-terminal acetyltransferase C
• Assessed muscle mass changes in a cancer cachexia model
• Evaluated CTSK expression levels and anabolic pathway activation.
• Inhibition led to reduced expression of CTSK
• Significant decrease in muscle wasting was observed
• Activation of anabolic pathways was confirmed.