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March 21, 2026Journal of the American Heart Association3 citationsOpen Access

Association of Rest‐Activity Rhythm and Sleep Regularity With Cardiometabolic Disease in the CARDIA Study

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SCSwaty ChapagaiPSPamela J. SchreinerSTS. Justin Thomas

Key Result

Less robust rest-activity rhythms and irregular sleep are associated with less favorable anthropometric and glycemic markers, but only weakly associated with blood pressure.

Key Points

  • The aim is to investigate how rest-activity rhythm and sleep regularity relate to cardiometabolic disease.
  • Analyzed data from the CARDIA study.
  • Evaluated anthropometric and glycemic markers.
  • Assessed blood pressure and racial differences.
  • Irregular rest-activity rhythms linked to worse anthropometric and glycemic markers.
  • Weak association found between sleep patterns and blood pressure.
  • Minimal racial differences in findings.

Structured PICO

Are less robust rest-activity rhythms and irregular sleep associated with cardiometabolic disease markers in the CARDIA Study?

P
Population
Participants in the CARDIA Study
I
Intervention
Less robust rest-activity rhythms and irregular sleep
O
Outcome
Cardiometabolic disease markers (anthropometric, glycemic, and blood pressure)surrogate

Irregular sleep and less robust rest-activity rhythms are associated with worse anthropometric and glycemic profiles, highlighting the potential cardiometabolic impact of sleep habits.

Abstract

Less robust rest-activity rhythms and irregular sleep were associated with less favorable anthropometric and glycemic markers but weakly associated with blood pressure, with few racial differences.

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Cite This Study

Chapagai et al. (2026) studied this question. Less robust rest-activity rhythms and irregular sleep are associated with less favorable anthropometric and glycemic markers, but only weakly associated with blood pressure.

synapsesocial.com/papers/69be35386e48c4981c67360chttps://doi.org/10.1161/jaha.125.046839
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Rest-activity rhythms across the lifespan: cross-sectional findings from the US representative National Health and Nutrition Examination Survey2023 · 50 citations
  2. 2A nonparametric methodological analysis of rest-activity rhythm in type 2 diabetes2018 · 21 citations
  3. 3Bright Light Therapy: Improved Sensitivity to Its Effects on Rest-Activity Rhythms in Alzheimer Patients by Application of Nonparametric Methods1999 · 609 citations
  4. 4Endogenous circadian system and circadian misalignment impact glucose tolerance via separate mechanisms in humans2015 · 517 citations
  5. 5The role of race and ethnicity in sleep, circadian rhythms and cardiovascular health2016 · 109 citations