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March 21, 2026ProteomesOpen Access

Emergence of Catalytic Activity in VRK3: Phosphoproteomic Insights into the Regulatory Network of a Former Pseudokinase

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Authors

ASAyadathil SujinaAFAmal FahmaSSSuhail Subair

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Overview

This review demonstrates the regulatory network of VRK3 phosphorylation in cellular pathways, suggesting therapeutic opportunities.

Key Points

  • The aim is to explore the phosphoregulatory network influencing VRK3 phosphorylation and its functional implications.
  • Conducted large-scale phosphoproteomic data integration.
  • Combined profiling and differential phosphorylation from 115 mass spectrometry studies.
  • Identified 32 high-confidence phosphorylation sites on VRK3.
  • Discovered significant phosphorylation sites at VRK3 (S59), (S82), and (S83).
  • Identified 33 potential upstream kinases regulating VRK3 activity.
  • Uncovered interactions with proteins involved in ERK, Hippo, and GPCR pathways.

Cite This Study

Sujina et al. (2026) studied this question.

synapsesocial.com/papers/69be356f6e48c4981c673a42https://doi.org/10.3390/proteomes14010014
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