The aim is to explore the association between genetic risk for late-onset Alzheimer's and brain volume changes in young children.
Analyzed brain volume trajectories in young children
Calculated polygenic scores for late-onset Alzheimer's disease
Correlated genetic risk factors with neurodevelopmental patterns
Identified a significant link between genetic risk and brain volume trajectories
Early brain development patterns reflect potential Alzheimer's disease vulnerability
Findings suggest critical periods in early development related to Alzheimer's risk
Abstract
These findings suggest that genetic risk for late-onset AD is linked to early neurodevelopmental patterns, indicating that AD vulnerability may originate during critical windows of early brain maturation.