Aerobic exercise stabilizes HIF1α and activates Nrf2/GPX4, reducing ferroptosis in diabetic cardiomyopathy, suggesting a potential therapeutic approach.
In summary, aerobic exercise increases P4HA1 expression and inhibits HIF1α hydroxylation, preventing its ubiquitination and degradation. This consequently activates the Nrf2/GPX4 signaling pathway, further exerting antioxidant effects, attenuating ferroptosis, and ultimately ameliorating DCM.
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Xie et al. (2026) studied this question.
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