Excessive manganese content in children’s multivitamin supplements: Potential for neurodevelopmental harm and other adverse health outcomes

Q: What does this research mean for the field?

Children's multivitamin supplements can cause manganese intake to exceed the Institute of Medicine's Tolerable Upper Intake Levels, particularly when combined with a normal diet, posing potential risks for neurodevelopmental harm. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Seth H. Frisbie; Erika J. Mitchell; Amy Hoeltge; Lindsey A. Pett; Molly G. Hoeltge

doi:10.1371/journal.pone.0343600

March 18, 2026PLoS ONEOpen Access

Excessive manganese content in children’s multivitamin supplements: Potential for neurodevelopmental harm and other adverse health outcomes

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Key Points

To investigate the manganese content in children's multivitamin supplements and its potential health risks.
Assessment of manganese levels in various children's multivitamin supplements.
Comparison with established tolerable upper intake levels (ULs) for manganese by IOM.
Evaluation of manganese exposure in relation to ordinary dietary intake.
Certain multivitamins exceed the established ULs for manganese.
High manganese intake may pose risks for neurodevelopment in children.
Suggests a need for regulatory oversight on supplement formulations.

Implication

Analysis shows excessive manganese in children's vitamins might harm development, suggesting careful consumption.

Abstract

Some children's multivitamin supplements may lead to exceedances of IOM ULs for Mn, especially when consumed as supplements to ordinary diets.

Discussion

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Cite This Study

Frisbie et al. (2026) studied this question.

synapsesocial.com/papers/69be35a96e48c4981c67410e https://doi.org/10.1371/journal.pone.0343600

View Full Paper

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Excessive manganese content in children’s multivitamin supplements: Potential for neurodevelopmental harm and other adverse health outcomes

Key Points

Implication

Abstract

Discussion

Cite This Study

Excessive manganese content in children’s multivitamin supplements: Potential for neurodevelopmental harm and other adverse health outcomes

Key Points

Implication

Abstract

Discussion

Cite This Study

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