Lipid-associated macrophage remodeling is present in the tumor microenvironment after high-grade glioma recurrence

Guanchao Xie; Hongqing Cai; Fuxing Zuo; Shen Tian; Hongsheng Zhang; Cheng Fang; Jianqi Xiao; JingHai Wan

doi:10.1016/j.ibneur.2026.03.007

March 1, 2026IBRO Neuroscience ReportsOpen Access

Lipid-associated macrophage remodeling is present in the tumor microenvironment after high-grade glioma recurrence

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Key Points

This research aims to examine the role of lipid-associated macrophages in the tumor microenvironment during high-grade glioma recurrence.
Analyzed clinical and RNA-seq data from the Chinese Glioma Genome Atlas (CGGA).
Utilized single-cell RNA sequencing (scRNA-seq) to investigate tumor microenvironment differences.
Applied R Seurat and ssGSEA scoring methods for data comparison.
Constructed a prognostic model using univariate Cox analyses on clinical features and ssGSEA scores.
Conducted Gene Ontology (GO) and KEGG analysis on lipid-associated macrophages' signature genes.
Identified a specific subpopulation of lipid-associated macrophages (LAMs) increased in recurrent gliomas.
LAMs serve as independent prognostic factors associated with poor prognosis in high-grade glioma.
Functional analysis indicates LAMs contribute to immune response dynamics and glioma-associated immune checkpoints.

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Implication

Observational analysis explores lipid-associated macrophage roles in tumor microenvironment remodeling after glioma recurrence, suggesting immune response implications.

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Cite This Study

Xie et al. (2026) studied this question.

synapsesocial.com/papers/69be35ba6e48c4981c6743c7 https://doi.org/10.1016/j.ibneur.2026.03.007

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Lipid-associated macrophage remodeling is present in the tumor microenvironment after high-grade glioma recurrence

Key Points

No abstract yet

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Implication

Discussion

Cite This Study

Lipid-associated macrophage remodeling is present in the tumor microenvironment after high-grade glioma recurrence

Key Points

No abstract yet

Ask about this paper

Implication

Discussion

Cite This Study

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