Amyloid-β “Co-assembles” with Coatomer Subunit Delta (δ-COP)

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Key Points

This research investigates the interaction between δ-COP and amyloid-β, particularly regarding its impact on intracellular trafficking in Alzheimer’s disease.
Conducted experiments to observe direct interactions between δ-COP and amyloid-β.
Developed a two-binding site model based on observed affinity.
Performed simulations to analyze the biophysical mechanisms behind the interactions.
Identified high-affinity and low-affinity binding sites between δ-COP and amyloid-β.
Demonstrated co-assembly-like β-sheet interactions between specific δ-COP and amyloid-β sequences.
Highlighting the significance of δ-COP I422 in the interaction mechanisms.

Experiments explore binding interactions of amyloid-β with δ-COP in Alzheimer’s disease, suggesting new insight into intracellular dynamics.

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Vlachou et al. (2026) studied this question.

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