This trial compares the effectiveness of psychedelic therapy and antidepressants, suggesting issues with positive narratives around therapy.
In trials of depression, PAT was not more effective than open-label TADs. Blinding made a difference for TADs, but not for PAT, confirming that PAT trials are effectively always open label. These results argue against highly optimistic narratives surrounding PAT and highlight the importance of blinding integrity.
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Williams et al. (2026) studied this question.
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