Prospective cross-sectional study evaluates RLS severity in children with celiac disease, indicating potential vitamin D and iron deficiency associations.
Key Points
To assess the prevalence and severity of restless legs syndrome (RLS) in children with celiac disease and investigate its associations with vitamin D and iron levels.
Conducted a prospective cross-sectional study with children aged 10-18 years.
Assessed RLS using the International Restless Legs Syndrome Study Group rating scale.
Recorded serum levels of vitamins and minerals including vitamin D and iron.
Performed statistical analyses including Spearman and Bayesian correlation analyses.
Children with celiac disease had significantly higher RLS severity than controls (median 6 vs. 0; p < 0.001).
Serum vitamin D levels negatively correlated with RLS severity (r = −0.251; p < 0.05).
RLS duration strongly correlated with severity (r = 0.838; p < 0.001).
No significant association was found between gluten-free diet adherence and RLS severity (p > 0.05).