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March 21, 2026Journal of Craniovertebral Junction and Spine1 citationsOpen Access

Normative segmental cervical lordosis distribution and sagittal vertical axis variations with T1 slope: Defining the role of the C2–C5 segment

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SBSadegh BagherzadehSKSrujan KopparapuFRFaramarz Roohollahi

Key Points

  • This study aims to determine how T1 slope affects cervical lordosis distribution and sagittal vertical axis in asymptomatic adults.
  • Analyzed standing lateral cervical radiographs from 85 asymptomatic adults.
  • Participants grouped by T1 slope levels: Low, Mid, and High.
  • Total cervical lordosis divided into upper and subaxial components.
  • SVA measurements taken at specific cervical segments.
  • Statistical analyses included ANOVA, Chi-square tests, Spearman correlations, and polynomial regression.
  • T1 slope correlated significantly with total cervical lordosis and subaxial cervical lordosis.
  • Total cervical lordosis increased with higher T1 slope, mainly driven by upper subaxial cervical lordosis.
  • Upper cervical lordosis contribution decreased, while lower cervical lordosis remained stable.
  • Apex of lordosis shifted caudally with increasing T1 slope.
  • Increased sagittal vertical axis at C2–C7 was linked to higher C6–C7 SVA.

Abstract

Background: The T1 slope (TS) is a major determinant of cervical sagittal alignment, yet its relationship to lordosis distribution and sagittal vertical axis (SVA) in asymptomatic adults remains insufficiently defined. This study evaluates how TS influences cervical lordosis segmentation, apex location, and SVA. Materials and Methods: Standing lateral cervical radiographs from 85 asymptomatic adults (mean age 50.5 ± 29.1 years; 45 males, 40 females) obtained between September 2024 and September 2025 were analyzed. Participants were grouped as Low-TS (30°, n = 12). Total cervical lordosis (TCL, OC7) was divided into upper cervical lordosis (UCL, occiput-C2) and subaxial cervical lordosis (SCL, C2–C7), with SCL further separated into upper SCL (USCL, C2–C5) and lower SCL (LSCL, C6–C7) components. SVA was measured at C2–C5 and C6–C7, and lordosis apex was determined from posterior tangent intersections. Analyses included analysis of variance, Chi-square, Spearman correlations, and polynomial regression ( P < 0.05). Results: TS correlated with TCL ( r = 0.526, P < 0.001), SCL ( P < 0.001), and C2–C7 SVA ( r = 0.265, P = 0.017), but not UCL ( P = 0.983). With increasing TS, TCL rose (low: 24.3° to high: 35.2°, P < 0.001), driven by USCL ( P = 0.002); UCL remained constant. UCL contribution decreased ( P = 0.006), and LSCL contribution was unchanged ( P = 0.198). The apex shifted caudally with rising TS ( P = 0.016). C2–C7 SVA increased due to higher C6–C7 SVA ( P = 0.020). Polynomial modeling confirmed a curvilinear TS-USCL relationship ( R ² = 0.38). Conclusion: TS drives a predictable caudal redistribution of cervical lordosis in asymptomatic adults, primarily through subaxial modulation, while upper cervical alignment remains preserved to maintain horizontal gaze.

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Cite This Study

Bagherzadeh et al. (2026) studied this question.

synapsesocial.com/papers/69be362d6e48c4981c674f2ehttps://doi.org/10.4103/jcvjs.jcvjs_11_26
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