Gabapentin Utilization and Adverse Effects Among US Hemodialysis Patients Diagnosed With Pruritus or Neuropathic Pain

Claudio Rigatto; Ting Lu; Thilo Schaufler; Despina Ruessmann; Ronald L. Pisoni; Brian Bieber; Chad Cogan; Angelo Karaboyas; Michael Strupp

doi:10.1016/j.xkme.2026.101341

March 1, 2026Kidney MedicineOpen Access

Gabapentin Utilization and Adverse Effects Among US Hemodialysis Patients Diagnosed With Pruritus or Neuropathic Pain

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Key Points

This analysis seeks to understand the utilization patterns and adverse effects of gabapentin in hemodialysis patients diagnosed with pruritus or neuropathic pain.
Retrospective analysis of registry data from the US Renal Data System (2016-2020)
Assessment of gabapentinoid use and dosing in hemodialysis patients
Evaluation of adverse effects using ICD-10 codes
Utilization of Cox-based recurrent event models to analyze associations
Adjustment for confounders and stratification by diagnosis groups
19% of neuropathic pain patients used gabapentin with an average dose of 503 mg/day
11% of pruritus patients used gabapentin with an average dose of 433 mg/day
Adverse effect rates per 100 patient-years included 37.8 for altered mental state and 20.4 for falls
Dose-response association observed, significant at p<0.001, especially in pruritus cases
Pregabalin was used by only 2%, with similar adverse effects as gabapentin

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Implication

Retrospective analysis reveals common adverse effects of gabapentin in hemodialysis patients with pain and itching, suggesting careful monitoring is needed.

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Rigatto et al. (2026) studied this question.

synapsesocial.com/papers/69be36416e48c4981c675080 https://doi.org/10.1016/j.xkme.2026.101341

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Gabapentin Utilization and Adverse Effects Among US Hemodialysis Patients Diagnosed With Pruritus or Neuropathic Pain

Key Points

No abstract yet

Ask about this paper

Implication

Discussion

Cite This Study

Gabapentin Utilization and Adverse Effects Among US Hemodialysis Patients Diagnosed With Pruritus or Neuropathic Pain

Key Points

No abstract yet

Ask about this paper

Implication

Discussion

Cite This Study

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