Topical corticosteroids and urea for the treatment of canine atopic dermatitis

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Key Points

The study aims to evaluate the effectiveness of different topical corticosteroids and urea combinations for treating canine atopic dermatitis.
Included seven dogs with canine atopic dermatitis exhibiting 28 limb lesions.
Applied three different creams: MFH, TA, and TA-Urea, using a randomized double-blind method.
Evaluated the severity using the Canine Atopic Dermatitis Extent and Severity Index (CADESI-04) at baseline, and after 7 and 14 days.
Average improvement rates in CADESI-04 were 32% and 50% for MFH, 34% and 57% for TA, and 29% and 54% for TA-Urea at 7 and 14 days, respectively.
All treatments showed significant improvement compared to baseline (p<0.05).
The medium-class TA and the very strong-class MFH showed equivalent treatment effects when mixed with urea.

Compares treatment effectiveness of corticosteroids and urea in dogs with atopic dermatitis, indicating similar outcomes.

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Matsuda et al. (2026) studied this question.

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