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Observational study reveals a link between clonal hematopoiesis and seropositive rheumatoid arthritis, suggesting genetic influences.
Age-related clonal hematopoiesis, including DNMT3A-CHIP, autosomal mCA and mLOY, are risk factors for incident SPRA but not SNRA, supporting a genotype- and serostatus-specific link between somatic mutation and RA, with the classical complement pathway as a potential modifier.
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Zhao et al. (2026) studied this question.
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