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March 21, 2026Organic & Biomolecular Chemistry0 citations

Facile Synthesis of Redox-Responsive Peptide Coacervates for Cytosolic Protein Delivery

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XHXiaona HanRHRuihui HanJYJiaxin Yang

Key Points

  • The aim is to create peptide coacervates that can effectively deliver proteins inside cells by responding to redox conditions.
  • Synthesize histidine-rich peptide coacervates
  • Examine cellular uptake of the coacervates
  • Investigate cargo release mechanisms linked to redox-responsive motifs
  • Coacervates showed excellent cellular uptake
  • Cargo release was effectively triggered by redox conditions
  • Demonstrated potential for efficient intracellular protein delivery

Abstract

Histidine-rich peptide (HBpep) coacervates are promising intracellular delivery vehicles due to their excellent cellular uptake. However, cargo release usually relies on redox-responsive motifs linked to lysine side chains via multi-step...

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Cite This Study

Han et al. (2025) studied this question.

synapsesocial.com/papers/69be36bf6e48c4981c675ec2https://doi.org/10.1039/d6ob00358c
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