Metagenomic Evaluation of Oral Microbiota in Patients Affected by Oral Lichen Planus: A Pilot Study

A. Dormiente; Leonardo Mancabelli; Marco Ventura; G. Longhi; G. Mergoni; M. Manfredi

doi:10.1111/odi.70296

March 17, 2026Oral DiseasesOpen Access

Metagenomic Evaluation of Oral Microbiota in Patients Affected by Oral Lichen Planus: A Pilot Study

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Key Points

To evaluate the oral microbiota in patients with oral lichen planus and identify associations with Candida overgrowth.
Conducted a metagenomic analysis of oral microbiota
Examined bacterial signatures during therapy
Assessed associations with corticosteroid use
Identified specific bacterial signatures corresponding with candida overgrowth
Found that oral microbiota remain stable during therapy
Suggested interactions may increase susceptibility to candidiasis

Implication

Pilot study evaluates bacterial signatures linked to candida overgrowth in patients, suggesting new interactions.

Abstract

Despite overall stability of the oral microbiota during therapy, specific bacterial signatures were associated with subsequent Candida overgrowth. These findings suggest that cross-kingdom interactions may influence susceptibility to corticosteroid-associated candidiasis and warrant validation in larger cohorts.

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Cite This Study

Dormiente et al. (2026) studied this question.

synapsesocial.com/papers/69be36d46e48c4981c675fb6 https://doi.org/10.1111/odi.70296

View Full Paper

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Metagenomic Evaluation of Oral Microbiota in Patients Affected by Oral Lichen Planus: A Pilot Study

Key Points

Implication

Abstract

Discussion

Cite This Study

Metagenomic Evaluation of Oral Microbiota in Patients Affected by Oral Lichen Planus: A Pilot Study

Key Points

Implication

Abstract

Discussion

Cite This Study

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