C-X-C Motif Chemokine Ligand 5 (CXCL5) Exhibits a U-Shaped Risk Profile for Mortality in Patients with Suspected Coronary Chest Pain

Figures

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  Figure 1. (a–c). Scatter plots based on the Pearson correlation coefficient between loge-transformed values of CXCL5 and the loge-transformed value of hsCRP (a) and PTX3 (b), respectively, and between the two latter (c), in 825, 768, and 795 RACS patients, respectively, admitted with chest pain of suspected coronary origin. The corresponding Spearman correlation coefficient is also shown.

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  Figure 2. (a,b). Kaplan–Meier plots based on quintile median values of CXCL5 in relation to all-cause mortality and composite endpoint, respectively, at 5-year follow-up in patients admitted with chest pain of suspected coronary origin. (Composite endpoint = all-cause mortality or MI or stroke.) The multivariable model included potential covariables selected using a stepwise algorithm added to the model containing CXCL5 quintiles.

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  Figure 3. (a,b). Forest plots showing hazard ratios based on the univariate and multivariable analyses of the association between median quintile values of CXCL5 and risk of (a) all-cause mortality and (b) composite endpoint, respectively, at 5-year follow-up in patients admitted with chest pain of suspected coronary origin. (Composite endpoint = all-cause mortality or MI or stroke.)

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  Figure 4. (a,b). Cubic spline interpolation of the quintile hazard ratios plotted against the mean of normalized baseline log(CXCL5) in relation to (a) all-cause mortality and (b) composite endpoint, respectively, adjusted for the covariates in the corresponding MVA model, at 5-year follow-up in patients admitted with chest pain of suspected coronary origin. Both plots demonstrate a U-shaped risk profile. (Composite endpoint = all-cause mortality or MI or stroke.)

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  Figure 5. Box plot of loge-transformed CXC motif chemokine ligand 5 (CXCL5) and high-sensitivity C-reactive protein (hsCRP) concentrations, respectively, in three groups of patients categorized by their TnT values. The Kruskal–Wallace test was used to check for differences across the TnT categories.