Key result
Age and gender are linked to lipid variability, led by low HDL-C in ~73%.
Cross-Sectional (n=14,691)
No
p-value: p=<0.001
There is a high prevalence of dyslipidemia, particularly low HDL-C and elevated triglycerides, among patients in Yemen, with significant age and gender variations.
Background: Dyslipidemia is a major modifiable risk factor for cardiovascular disease. Despite its global burden, data from Yemen remain scarce. This study aimed to determine the prevalence of lipid abnormalities and their associations with age, gender, and vitamin D deficiency among patients attending a specialized endocrinology and diabetes clinic in Ibb, Yemen. Methods: We conducted a cross‑sectional study of 14,691 individuals in Ibb, Yemen, using electronic medical records from the Medical City Complex (July 2018-January 2026). Demographic and lipid parameters were extracted, with categories defined by international guidelines. Statistical analyses were performed using appropriate parametric and non‑parametric tests, with significance set at p < 0.05. Results: A total of 14,691 patients were analyzed. Most had normal total cholesterol (85.2%), while borderline or high levels were more frequent in females. Triglyceride abnormalities were common, with nearly one‑quarter showing high values (>199 mg/dL), slightly more in males. Low high‑density lipoprotein cholesterol (HDL‑C) was highly prevalent (72.9%), while high HDL‑C was rare (0.9%). Low‑density lipoprotein cholesterol (LDL‑C) abnormalities were found in 8.6%, more frequently in females. Both gender and age were strongly associated with lipid variability (p < 0.001): females consistently exhibited higher total cholesterol, LDL‑C, and HDL‑C, whereas males had higher triglycerides. Middle‑aged adults carried the greatest burden of abnormal triglycerides and LDL‑C, while older adults were more prone to low HDL‑C. Overall, gender and age emerged as the strongest determinants of dyslipidemia. Conclusion: Lipid abnormalities are widespread in this Yemeni cohort, with low HDL‑C and elevated triglycerides being the most prominent. Gender and age were the strongest determinants of lipid variability, underscoring the need for sex‑ and age‑specific strategies in cardiovascular risk management. These findings align with international evidence and highlight the importance of tailored prevention policies in resource‑limited settings.
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Al-Hetar et al. (2026) conducted a cross-sectional in Dyslipidemia (n=14,691). Age and gender was evaluated on Lipid variability (p=<0.001). Age and gender were strongly associated with lipid variability (P<0.001), with low HDL-C (72.9%) and elevated triglycerides being the most prominent abnormalities.
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