Impact of Duration of Outpatient Sodium Zirconium Cyclosilicate Therapy on Hyperkalemia-Related Health Care Resource Utilization: A Matched Cohort Analysis

Abiy Agiro; Erin Cook; Ali Greatsinger; FAN MU; Jess Smith; Emily Reichert; Ellen Colman; Arun Malhotra

doi:10.1016/j.xkme.2026.101340

March 1, 2026Kidney MedicineOpen Access

Impact of Duration of Outpatient Sodium Zirconium Cyclosilicate Therapy on Hyperkalemia-Related Health Care Resource Utilization: A Matched Cohort Analysis

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Key Points

This analysis aimed to examine how the duration of sodium zirconium cyclosilicate therapy affects hyperkalemia-related healthcare utilization outcomes.
Conducted a retrospective matched observational cohort study using US claims data.
Compared short-term (30 days) and long-term (over 90 days) sodium zirconium cyclosilicate users.
Matched users based on various demographic and clinical factors.
Used generalized estimating equations for outcome comparisons.
Long-term sodium zirconium cyclosilicate users had a 40% lower rate of hyperkalemia-related hospitalizations or ED visits compared to short-term users.
Observed a 36% lower rate of hyperkalemia-related hospitalizations among long-term users.
Long-term users also had a 49% lower rate of hyperkalemia-related ED visits.
Rates of hyperkalemia-related outpatient visits were similar between both groups.

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Implication

Matched cohort analysis shows reduced hyperkalemia-related hospitalizations in long-term sodium zirconium cyclosilicate users, indicating potential benefits of extended therapy.

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Agiro et al. (2026) studied this question.

synapsesocial.com/papers/69be36e36e48c4981c6761e0 https://doi.org/10.1016/j.xkme.2026.101340

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Impact of Duration of Outpatient Sodium Zirconium Cyclosilicate Therapy on Hyperkalemia-Related Health Care Resource Utilization: A Matched Cohort Analysis

Key Points

No abstract yet

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Implication

Discussion

Cite This Study

Impact of Duration of Outpatient Sodium Zirconium Cyclosilicate Therapy on Hyperkalemia-Related Health Care Resource Utilization: A Matched Cohort Analysis

Key Points

No abstract yet

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Implication

Discussion

Cite This Study

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