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March 21, 2026Scientific ReportsOpen Access

Modulation of resting macrophage activity via low-level laser therapy (LLLT) and α-lipoic acid: an in vitro study using a PCL-based biomaterial

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Authors

AŚAnna Ścisłowska-CzarneckaAMAleksandra MatułaESEwa Stodolak-Zych

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Overview

In vitro study evaluates LLLT and α-lipoic acid's impact on macrophage activity, suggesting improved tissue repair.

Key Points

  • The study aims to evaluate how low-level laser therapy and α-lipoic acid influence resting macrophage function.
  • Culturing RAW 264.7 macrophages on LA-modified PCL membranes
  • Conducting physicochemical analyses to confirm LA incorporation
  • Applying LLLT (808 nm, pulsed mode) to assess effects on macrophage activity
  • Measuring macrophage viability, cytokine secretion, and matrix metalloproteinase activity
  • LLLT modulated the activity of MMP-2 and MMP-9 without affecting macrophage viability
  • LA-modified membranes increased macrophage viability and reduced inflammatory markers
  • Combination treatment showed further improvements in macrophage survival and reduced MCP-1 levels
  • LA treatment enhanced antioxidant capacity without altering oxidative potential

Cite This Study

Ścisłowska-Czarnecka et al. (2026) studied this question.

synapsesocial.com/papers/69be37096e48c4981c6766a4https://doi.org/10.1038/s41598-026-43877-y
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