Predictors of poor kidney function in patients with emphysematous pyelonephritis: a retrospective observational study

Background: Emphysematous pyelonephritis (EPN) is a well-known clinical condition characterized by an aggressive, gas-forming infection of the kidney caused by uropathogenic bacteria. There is growing interest in identifying the effects of EPN on long-term renal function and the factors that can help predict its impact. Objectives: This study evaluated risk factors for the development of poorly functioning kidneys (PFK) in patients diagnosed with EPN. Design: A retrospective study was conducted at a university teaching hospital on patients with EPN from January 2019 to December 2024. Methods: Data were collected from the prospectively maintained patient records, and patient demographics, comorbidities, clinical presentation, laboratory investigations, imaging characteristics, and interventions were analyzed. PFKs were defined as those with less than 15% differential function on radionuclide renography performed at follow-up. Data were analyzed using SPSS version 23 (IBM Corp.). A p -value 200 mg/dL ( p 50% parenchymal involvement on imaging ( p 50% parenchymal involvement on initial imaging was an independent and significant predictor of PFK. Conclusion: EPN is a fulminant renal infection with a high risk of renal functional deterioration. Renal parenchymal involvement of >50% on initial imaging emerged as the most significant and independent predictor of poor renal function. Additional contributory factors included RBS >200 mg/dL, Huang-Tseng Class 3b, and persistence of gas in the renal parenchyma on follow-up. Recognizing these clinical and radiological predictors can support early risk stratification, guide patient counseling, and inform individualized management strategies aimed at preserving renal function.