This cover feature demonstrates a novel method for converting pyridines to anilines, suggesting new avenues for molecular modification.
The Cover Feature shows a skeletal-editing strategy that transforms pyridines into anilines through carbene insertion followed by nitrogen isomerization. By externalizing the original pyridine nitrogen to the ipso or ortho position without changing the ring size, this method enables direct pyridine-to-aniline conversion and provides a new platform for nitrogen scanning, scaffold remodeling, and late-stage diversification of bioactive molecules. For more details, see the Research Article by Y. Luo, J. Dai, Y. Wei and C. Min (DOI: 10.1002/ceur.202500410).
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Luo et al. (2026) studied this question.
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