Mendelian randomization shows increased risk of adverse pregnancy outcomes linked to autoimmune genetic liability, suggesting the need for further exploration.
We observed higher genetic liability to Hashimoto's thyroiditis, type 1 diabetes, and rheumatic conditions causes increased risk of adverse pregnancy outcomes. Further research is warranted to explore the immune mechanisms underlying these relationships, and identify targets for prevention.
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Aiton et al. (2026) studied this question.
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