The Role of Hyperbaric Oxygen Therapy (Hbot) and Platelet-Rich Plasma (Prp) for Tissue Regeneration

Background: Hyperbaric oxygen therapy (HBOT) and platelet-rich plasma (PRP) have individually demonstrated potential in enhancing tissue regeneration through improved oxygenation and growth fаctor delivery. This study evaluated the clinical outcomes of combined therapeutic approach using HBOT and PRP in patients with early signs of compromised tissue perfusion after surgery. Methods: We conducted a prospective case series of four patients presenting with clinical signs of localized ischemia. Аll patients underwent therapy consisting of series of HBOT sessions combined with PRP injections directly into the affected tissue. Tissue perfusion and healing progression were monitored clinically on daily basis. Photographic documentation was used to track the progress. Results: All four patients demonstrated improvement in tissue color, warmth and healing process following the start of the combinational therapy. The beginning of the revascularization was observed within 3-5 days of treatment initiation. None of the patients required surgical revision or debridement. There were no adverse effects. The combined approach appeared to resolve early ischemic changes and accelerate wound closure. Conclusion: The combined use of HBOT and PRP provide a synergistic effect in enhancing tissue recovery in patients with postoperative wound ischemia. This approach may reduce the need for surgical procedures and improve aesthetic and functional outcomes.