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March 21, 2026Basic & Clinical Pharmacology & Toxicology2 citationsOpen Access

6‐Nitrodopamine Potentiates Catecholamine‐Induced Ca 2+ i Release in Human Aortic Smooth Muscle and Modulates Vascular Smooth Muscle Contractility

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JBJosé Britto‐JúniorALAntonio Tiago LimaSQShuaihua Qiao

Key Result

6-Nitrodopamine enhances catecholamine-driven vasoconstriction and intracellular calcium release in human aortic smooth muscle cells by modulating voltage-gated sodium channels.

Key Points

  • This research aims to explore how 6-nitrodopamine affects calcium release and contractility in vascular smooth muscle.
  • Investigated the effects of 6-nitrodopamine on intracellular calcium levels in human aortic smooth muscle cells (HASMCs).
  • Assessed the impact of 6-nitrodopamine on catecholamine-induced vasoconstriction.
  • Utilized TTX to determine the involvement of voltage-gated sodium channels.
  • 6-nitrodopamine significantly enhances calcium release in HASMCs during catecholamine stimulation.
  • Catecholamine-driven vasoconstriction is increased by 6-nitrodopamine.
  • The effects of 6-nitrodopamine are blocked by TTX, indicating modulation of sodium channels.

Structured PICO

P
Population
Human Aortic Smooth Muscle Cells (HASMCs)
I
Intervention
6-Nitrodopamine (6-ND)
O
Outcome
Modulation of intracellular calcium ([Ca2+]i) and catecholamine-driven vasoconstrictionsurrogate

6-Nitrodopamine acts upstream of calcium entry via voltage-gated sodium channels to potentiate catecholamine-induced vasoconstriction in human aortic smooth muscle.

Abstract

6-ND is a potent modulator of Ca2+i in HASMCs and enhances catecholamine-driven vasoconstriction. Both effects are blocked by TTX, indicating that 6-ND modulates voltage-gated sodium channels upstream of Ca2+ entry/release in vascular smooth muscle cells.

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Cite This Study

Britto‐Júnior et al. (2026) studied this question. 6-Nitrodopamine enhances catecholamine-driven vasoconstriction and intracellular calcium release in human aortic smooth muscle cells by modulating voltage-gated sodium channels.

synapsesocial.com/papers/69be37866e48c4981c677385https://doi.org/10.1111/bcpt.70224
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 16-Nitrodopamine potently increases intracellular calcium (Ca2+i) and potentiates catecholamine-induced Ca2+i release in human aortic smooth muscle and human aortic endothelial cells2025
  2. 2Correction to “6‐Nitrodopamine Potentiates Catecholamine‐Induced Ca <sup>2+</sup> <sub>i</sub> Release in Human Aortic Smooth Muscle and Modulates Vascular Smooth Muscle Contractility”2026
  3. 36-nitrodopamine potentiates contractions of rat isolated vas deferens induced by noradrenaline, adrenaline, dopamine and electric field stimulation2023
  4. 4Endothelium-Derived Dopamine and 6-Nitrodopamine in the Cardiovascular System2023 · 35 citations
  5. 5Abstract Wed176: 6-Nitrodopamine potentiates the positive chronotopic and inotropic effect induced by noradrenaline in the rat isolated heart2025