A case report demonstrates anesthetic management challenges in total hip replacement for a patient with alkaptonuria, suggesting tailored strategies are crucial.
Alkaptonuria is a rare inherited genetic disorder of tyrosine metabolism characterized by homogentisic aciduria, ochronosis, and arthritis. Ochronosis leads to bluish-blackish pigmentation of connective tissues with multiple system involvement (musculoskeletal, ocular, renal, respiratory, airway, cardiovascular, genitourinary, and cutaneous). We report the perioperative anesthetic management of a 71-year-old patient with alkaptonuria and multiple comorbidities scheduled for a total hip replacement. He was a known case of alkaptonuria and hypertension, with a history of atrial fibrillation. This case highlights the anesthetic challenges posed by multisystem involvement, associated comorbidities, and multiple drug allergies, emphasizing the need for a carefully tailored and safe anaesthetic strategy.
No takes yet. Share an insight, caveat, or question.
D’souza et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: