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March 21, 2026European Journal of Organic Chemistry

Stereoselective Synthesis of C1–C18 Fragment with Macrocyclic Framework of Marine Cytotoxic (‐)‐Callyspongiolide

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Authors

SPSankara Rao PattaIndian Institute of Chemical TechnologyNGNaresh GantasalaUniversity of MinnesotaPDPradeep P. DesaleIndian Institute of Chemical Technology

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Implication

Stereoselective synthesis demonstrates the potential for constructing complex macrolide frameworks, indicating its relevance for drug development.

Key Points

  • The aim is to develop a strategy for synthesizing the C1–C18 fragment of callyspongiolide with a macrocyclic structure.
  • Utilized a convergent strategy for fragment synthesis
  • Employing asymmetric alkylation and Evans aldol reaction for high stereocontrol
  • Coupled two key fragments via esterification
  • Implemented ring-closing metathesis for macrocycle formation
  • Successfully constructed the C1–C18 fragment with a protected 14-membered macrocyclic core
  • Achieved high levels of stereocontrol throughout the synthesis
  • Set the foundation for the total synthesis of callyspongiolide

Cite This Study

Patta et al. (2026) studied this question.

synapsesocial.com/papers/69be37b96e48c4981c6779e4https://doi.org/10.1002/ejoc.202501043
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