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March 21, 2026Circulation3 citationsOpen Access

Memantine for Premature Atrial Contractions: A Phase 2 Randomized Clinical Trial

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YSYing ShenCZChunyu ZengCZChunyu Zeng

Key Points

  • Evaluate the efficacy of memantine in reducing premature atrial contractions.
  • Conducted as a randomized clinical trial
  • Participants given memantine or placebo
  • Monitored for frequency of atrial contractions
  • Memantine showed a reduction in premature atrial contractions
  • Improvement observed in participants receiving active treatment
  • Safety profile similar to placebo

Abstract

URL: https://www.clinicaltrials.gov; Unique identifier: NCT06501638.

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Trending Research#2 this week

Recent publication; discussed in arrhythmia communities; potential new use for existing drug.

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Cite This Study

Shen et al. (2026) studied this question. Memantine is currently under investigation for the treatment of premature atrial contractions in a phase 2 randomized clinical trial.

synapsesocial.com/papers/69be37dd6e48c4981c677e50https://doi.org/10.1161/circulationaha.125.079023
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