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March 21, 2026Journal of Nanobiotechnology2 citationsOpen Access

Curcuma longa-derived extracellular vesicle-like particles ameliorate retinal neovascularization through HIF-1α and NRF2 signaling

YCYing ChenDPDe-Wei PengSJSheng-Rui Jiang

Key Points

  • This research aims to explore the effects of curcuma longa-derived extracellular vesicle-like particles (CL-EVLPs) on retinal neovascularization.
  • Evaluated CL-EVLPs for their ability to suppress retinal neovascularization
  • Analyzed the inhibition of the HIF-1α/VEGFA/ERK signaling axis
  • Assessed activation of the NRF2/HO-1 pathway
  • CL-EVLPs significantly inhibited retinal neovascularization
  • Demonstrated a reduction in the HIF-1α/VEGFA/ERK pathway activity
  • Activated NRF2/HO-1 signaling, suggesting protective effects

Abstract

CL-EVLPs effectively suppress retinal neovascularization by inhibiting the HIF-1α/VEGFA/ERK axis and activating the NRF2/HO-1 pathway. This study suggests that CL-EVLPs, as a multitarget therapeutic strategy, hold promising clinical translational potential for the treatment of retinal neovascular diseases.

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Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/69be38126e48c4981c678438https://doi.org/10.1186/s12951-026-04303-7
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