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March 21, 2026Chemical Communications3 citationsOpen Access

Palladium-Catalyzed Denitrative C-N Coupling of Amides with Nitroarenes Enabled by Al(OTf) 3

LYLinjie YangXWXuejie WangWCWanzhi Chen

Key Points

  • The research aims to develop a more efficient method for synthesizing N-aryl amides from amides and nitroarenes.
  • Utilized Pd as the catalyst for C-N coupling reactions
  • Employed Al(OTf)3 to enhance the reaction efficiency
  • Investigated the coupling of various amide nucleophiles with nitroarene feedstocks
  • Achieved direct synthesis of N-aryl amides with high atom economy
  • Highlighted the essential role of Al(OTf)3 in promoting the reaction
  • Demonstrated compatibility with multiple nitroarene substrates

Abstract

We report a Pd-catalyzed denitrative C-N coupling of amide nucleophiles with nitroarenes, providing direct and atomeconomical access to N-aryl amides from readily available nitroarene feedstocks. Al(OTf)3 is essential, both promoting...

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Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/69be38356e48c4981c67880ehttps://doi.org/10.1039/d6cc00697c
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