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March 21, 2026Journal of Clinical Biochemistry and NutritionOpen Access

Mechanistic insights and evidence-based management of metabolic dysfunction-associated steatotic liver disease (MASLD; formerly NAFLD) through combined diet and exercise interventions: an evidence-based narrative review

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Authors

YCYu ChenRLRongqin LiuRHRenli Huang

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Overview

Evidence-based narrative review shows combined diet and exercise improve metabolic outcomes in MASLD, suggesting effective lifestyle management strategies.

Key Points

  • The aim is to synthesize evidence on diet-plus-exercise strategies for managing MASLD.
  • Conducted evidence-based narrative review with structured literature search.
  • Prioritized randomized or controlled trials of combined dietary and exercise interventions.
  • Used mechanistic studies for biological context and qualitative synthesis to summarize findings.
  • Combined dietary and exercise interventions show synergistic effects on metabolic and inflammatory pathways.
  • Interventions improve hepatic steatosis and metabolic profiles more effectively than single interventions.
  • Integrated programs supported by digital health can optimize lifestyle interventions.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/69be38446e48c4981c6788c7https://doi.org/10.3164/jcbn.25-259
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