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March 18, 2026Journal of Investigative SurgeryOpen Access

DNA Methylation-Regulated FAM107A Affects Colorectal Carcinogenesis by Inhibiting FOXM1

Yue Liu Jinwei Sun Yuhua Shi Lei Wang Xinyue Zhang Lizhou Chen

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Key Points

The study aims to explore the role of the DNMT1/FAM107A/FOXM1 pathway in colorectal cancer (CRC).
Hypothesis-driven analysis of molecular interactions
Focus on the DNMT1, FAM107A, and FOXM1 proteins
Evaluation of their roles in CRC development
FAM107A is identified as a key inhibitor of FOXM1
The interplay between DNMT1 and FAM107A significantly affects CRC progression
Implications suggest potential therapeutic targets in colorectal cancer treatment

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Implication

This research examines how FAM107A influences colorectal carcinogenesis through the DNMT1/FOXM1 axis, suggesting new treatment targets.

Abstract

These results hypothesize that the occurrence and development of CRC are mainly mediated by the DNMT1/FAM107A/FOXM1 axis.

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Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69be387d6e48c4981c678ed9 https://doi.org/10.1080/08941939.2026.2633933

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