Investigations into Linker Effects of DNA-VHL Ligand Conjugates by Multiplexed Affinity Measurements Using Focal Molography

Pascal Raschke; Simona Notova; Volker Gatterdam; Andreas Frutiger; Andreas Brunschweiger

doi:10.1039/d6cb00011h

January 1, 2025RSC Chemical BiologyOpen Access

Investigations into Linker Effects of DNA-VHL Ligand Conjugates by Multiplexed Affinity Measurements Using Focal Molography

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Key Points

The research aims to explore how the linker structures affect the binding of DNA-VHL ligand conjugates to target proteins.
Utilized focal molography for affinity measurements
Examined various DNA-tagged compounds
Analyzed kinetic binding properties
Identified specific linker structures that enhance binding efficiency
Demonstrated varying kinetic profiles for different ligands
Revealed potential for improved design of nucleic acid-based PROTACs

Implication

Investigations demonstrate kinetic binding properties of DNA-tagged compounds in PROTACs, suggesting new insights into drug design.

Abstract

The determination of kinetic binding properties of DNA-tagged compounds binding to a target protein is an important step in the development of nucleic acid-based proteolysis targeting chimeras (PROTACs). Focal molography...

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Cite This Study

Raschke et al. (2025) studied this question.

synapsesocial.com/papers/69be387d6e48c4981c678f70 https://doi.org/10.1039/d6cb00011h

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Investigations into Linker Effects of DNA-VHL Ligand Conjugates by Multiplexed Affinity Measurements Using Focal Molography

Key Points

Implication

Abstract

Discussion

Cite This Study

Investigations into Linker Effects of DNA-VHL Ligand Conjugates by Multiplexed Affinity Measurements Using Focal Molography

Key Points

Implication

Abstract

Discussion

Cite This Study

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