Volumetric analysis reveals hyper-reflective Henle fiber layer changes in age-related macular degeneration, indicating significant retinal pathology.
Hyper-reflective HFL regions are a robust marker of outer retinal pathology in AMD. Structural changes such as drusen, fluid, and atrophy likely alter HFL orientation, leading to hyper-reflectivity. Although not specific to any single pathology, the hr-HFL reliably reflects the presence of AMD-related pathological changes.
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Wang et al. (2026) studied this question.
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