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The study investigates how METTL3 influences FASN mRNA stability and its impact on DLBCL progression.

March 21, 2026Cell & Bioscience0 citationsOpen Access

METTL3 stabilizes FASN mRNA by mediating m6A modification to promote malignant progression of diffuse large B-cell lymphoma

XSXiangxiang SongJiangxi Provincial Cancer Hospital YZYun ZhongJiangxi Provincial Cancer Hospital NYNasha Yu

Key Points

The study investigates how METTL3 influences FASN mRNA stability and its impact on DLBCL progression.
Analyzed METTL3's role in FASN mRNA stabilization
Assessed signaling pathways involved in DLBCL progression
Examined ER stress response mechanisms
METTL3 significantly enhances FASN expression through m6A modification
Activation of PI3K/AKT and MAPK/ERK pathways was observed
ER stress response was inhibited in METTL3/FASN-high DLBCL

Abstract

METTL3 stabilizes FASN expression through m6A modification, thereby facilitating the DLBCL progression by activating the PI3K/AKT and MAPK/ERK signaling pathways and inhibiting the ER stress response pathway. The METTL3/FASN axis represents a potential therapeutic target, especially in METTL3/FASN-high DLBCL subgroups.

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