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March 21, 2026RSC Advances2 citationsOpen Access

Molecular and physicochemical arrangement of chitosan–ibuprofen matrices for topical drug delivery on skin: preparation impact

BGBarbara GierobaVVVladyslav VivcharenkoGKGrzegorz Kalisz

Key Points

  • This research aims to explore the impact of the preparation process on chitosan-ibuprofen matrices for enhanced topical drug delivery.
  • Developed chitosan-ibuprofen matrices through various preparation techniques.
  • Evaluated physicochemical properties to determine their impact on drug release.
  • Conducted in vitro assessments of drug delivery efficiency on skin models.
  • Matrices exhibited altered physicochemical properties based on preparation methods.
  • Enhanced drug release rates were observed in optimized matrix formulations.
  • Demonstrated potential for improved patient-centric topical applications.

Abstract

Recent advances in modern medicine emphasize patient-centric and personalized therapeutic strategies, particularly for chronic and regenerative applications.

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Cite This Study

Gieroba et al. (2026) studied this question.

synapsesocial.com/papers/69be38906e48c4981c6791d8https://doi.org/10.1039/d6ra00296j
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