Molecular and physicochemical arrangement of chitosan–ibuprofen matrices for topical drug delivery on skin: preparation impact

January 1, 2026RSC AdvancesOpen Access

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Key Points

This research aims to explore the impact of the preparation process on chitosan-ibuprofen matrices for enhanced topical drug delivery.
Developed chitosan-ibuprofen matrices through various preparation techniques.
Evaluated physicochemical properties to determine their impact on drug release.
Conducted in vitro assessments of drug delivery efficiency on skin models.
Matrices exhibited altered physicochemical properties based on preparation methods.
Enhanced drug release rates were observed in optimized matrix formulations.
Demonstrated potential for improved patient-centric topical applications.

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Researchers demonstrate improved drug delivery in skin using chitosan-ibuprofen matrices, suggesting enhanced therapeutic strategies.

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Gieroba et al. (2026) studied this question.

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