Observational findings reveal NFAT1+ microglia enhance recovery through angiogenesis in ischemic stroke, suggesting a new treatment direction.
Microglial NFAT1 drives antiinflammatory polarization and angiogenesis via the HAS3-HA-LYVE1-Wnt/β-catenin axis, ultimately improving stroke recovery. These findings reveal a previously unrecognized mechanism of neurovascular repair and highlight NFAT1⁺ microglia as a promising therapeutic target for ischemic stroke.
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Zhang et al. (2026) studied this question.
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