Electrochemically Cooperative Halogen Cation Delivery Enables Modular Electrophilic Haloesterification of Both Activated and Unactivated Alkenes

Hehuan Xu; Duo-Duo Qian; Yi Fan; Jia-Jia Zhang; Chang-Le Guo; Hai-Chao Xu

doi:10.1039/d6sc00279j

January 1, 2026Chemical ScienceOpen Access

Electrochemically Cooperative Halogen Cation Delivery Enables Modular Electrophilic Haloesterification of Both Activated and Unactivated Alkenes

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Key Points

The study aims to develop a more versatile method for haloesterification of both activated and unactivated alkenes.
Utilized electrochemical delivery of halogen cations to facilitate ester synthesis.
Explored the reactivity of different types of alkenes, including electron-deficient variants.
Demonstrated the process using a range of reactions to assess modularity and efficiency.
Successfully haloesterified both activated and unactivated alkenes.
Showed improved reaction conditions leading to higher yields for electron-deficient alkenes.
Outlined the potential of this method for expanding applications in organic chemistry.

Implication

Novel methods enable efficient haloesterification of varied alkenes, suggesting broader applications in organic synthesis.

Abstract

Intermolecular haloesterification of alkenes is a practical platform for modular ester synthesis. However, current methods are restricted to aryl activated and directing-group contained alkenes, leaving low-reactivity, electron-deficient alkenes with alkyl...

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Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/69be38a46e48c4981c6792be https://doi.org/10.1039/d6sc00279j

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Electrochemically Cooperative Halogen Cation Delivery Enables Modular Electrophilic Haloesterification of Both Activated and Unactivated Alkenes

Key Points

Implication

Abstract

Discussion

Cite This Study

Electrochemically Cooperative Halogen Cation Delivery Enables Modular Electrophilic Haloesterification of Both Activated and Unactivated Alkenes

Key Points

Implication

Abstract

Discussion

Cite This Study

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